Although born in Delaware in colonial America, Samuel Davies retained much of the flavor of his family's Welsh background. One commentator observed that as a pastor and evangelist, Davies delivered sermons "with all the pathos of his Welsh soul."

From his youth, he sensed that God had a call on his life, and he totally immersed himself in it. He owed much of that sense of God's call to the strong faith of his parents, and particularly his mother. He once said, "I am a son of prayer, like my namesake, Samuel. My mother called me Samuel, because, she said, I have asked him of the Lord."

Davies impacted thousands of people, including Patrick Henry, who played a key role during the American Revolution. As a boy, Henry often heard Davies preach, and he acknowledged his influence. In addition, pastors throughout the world read and studied Davies' sermons, which went through four editions in the United States and nine in England.

Throughout his life, Davies constantly battled sickness. Faced with these struggles, others might have cut back their efforts or reduced their schedule. But Davies would let nothing deter him from preaching. In fact, he found strength in being faithful to his call. He once wrote, "In my sickness, I found the unspeakable importance of a Mediator in a religion for sinners." He found all his sufficiency in Christ! What was his message? "It is Jesus whom you preach." He is "an all-sufficient Savior. None but Christ, none but Christ!"